| Game | Year |
|---|
| Safecracker: The Ultimate Puzzle Adventure | 2006 |
| Sagebrush | 2018 |
| Salammbô: Battle for Carthage | 2003 |
| Sally Face: Episode One - Strange Neighbors | 2019 |
| Sam and Max, Season 1 Episode 1: Culture Shock | 2006 |
| Sam and Max, Season 1 Episode 2: Situation: Comedy | 2006 |
| Sam and Max, Season 1 Episode 3: The Mole, the Mob, and the Meatball | 2007 |
| Sam and Max, Season 1 Episode 4: Abe Lincoln Must Die | 2007 |
| Sam and Max, Season 1 Episode 5: Reality 2.0 | 2007 |
| Sam and Max, Season 1 Episode 6: Bright Side of the Moon | 2007 |
| Sam and Max, Season 2 Episode 1: Ice Station Santa | 2007 |
| Sam and Max, Season 2 Episode 2: Moai Better Blues | 2008 |
| Sam and Max, Season 2 Episode 3: Night of the Raving Dead | 2008 |
| Sam and Max, Season 2 Episode 4: Chariots of the Dogs | 2008 |
| Sam and Max, Season 2 Episode 5: What's New, Beelzebub? | 2008 |
| Sam and Max, Season 3 Episode 1: The Penal Zone | 2010 |
| Sam and Max, Season 3 Episode 2: The Tomb of Sammun-Mak | 2010 |
| Sam and Max, Season 3 Episode 3: They Stole Max's Brain! | 2010 |
| Sam and Max, Season 3 Episode 4: Beyond the Alley of the Dolls | 2010 |
| Sam and Max, Season 3 Episode 5: The City That Dares Not Sleep | 2010 |
| Sam and Max Hit the Road | 1993 |
| Samantha Swift 1: Samantha Swift and the Hidden Roses of Athena | 2008 |
| Samantha Swift 2: Samantha Swift and the Golden Touch | 2009 |
| The Samaritan Paradox | 2014 |
| Samorost 1 | 2003 |
| Samorost 2 | 2005 |
| Samorost 3 | 2016 |
| The Sancho's Island | 2005 |
| Sandra and Woo in the Cursed Adventure | 2017 |
| Sanitarium | 1998 |
| Sanity: Aiken's Artifact | 2000 |
| Santa Fe Mysteries: Sacred Ground | 1996 |
| Santa Fe Mysteries: The Elk Moon Murder | 1996 |
| Santa's Secret Valley | 1998 |
| Scael | 2017 |
| Scarlett Adventures: Episode 1 - Scarlett and the Spark of Life | 2010 |
| Scavenger Hunter | 2006 |
| Scéal | 2016 |
| Schizm 1: Mysterious Journey | 2001 |
| Schizm 2: Chameleon | 2003 |
| Scooby-Doo: Classic Creep Capers | 2001 |
| Scooby-Doo! Phantom of the Knight | 2000 |
| Scooby-Doo! Showdown in Ghost Town | 2000 |
| Scooby Doo! The Mystery of the Fun Park Phantom | 1999 |
| Scooby Doo Case File 1: The Glowing Bug Man | 2002 |
| Scooby Doo Jinx At The Sphinx | 2001 |
| Scratches | 2006 |
| The Scroll | 1995 |
| Sea of Giants 1: Hidden Island | 2014 |
| Sea Of Giants 2: Monument Island | 2017 |
| The Sea Will Claim Everything | 2012 |
| The Search | 2017 |
| Search for the Golden Dolphin | 1999 |
| A Second Face: The Eye of Geltz is Watching You | 2008 |
| Secret Files: Sam Peters | 2013 |
| Secret Files 1: Tunguska | 2006 |
| Secret Files 2: Puritas Cordis | 2009 |
| Secret Files 3 | 2012 |
| Secret Mission | 1993 |
| Secret Missions: Mata Hari and the Kaiser's Submarines | 2008 |
| The Secret Monster Society: Episode 1 - Monsters, Fires and Forbidden Forests | 2016 |
| The Secret of Chateau de Moreau | 2011 |
| The Secret of Middle City | 2015 |
| The Secrets of Alamut | 2001 |
| The Secrets of Atlantis: The Sacred Legacy | 2006 |
| The Secrets of Da Vinci: The Forbidden Manuscript | 2006 |
| The Secrets of Jesus | 2019 |
| Secrets of the Luxor | 1996 |
| Secrets of the Pyramids | 1994 |
| Sense – A Cyberpunk Ghost Story | 2020 |
| Sentience: The Android's Tale | 2017 |
| Sentient | 1997 |
| Sentinel: Descendants in Time | 2004 |
| SerpentHead Revisited | 2003 |
| Sethi and the Crown Of Egypt | 2001 |
| Sethi and the Inca Wizard | 2001 |
| Seven Doors | 2020 |
| The Sexy Brutale | 2018 |
| Shadow Of Memories | 2001 |
| Shadowgate | 1987 |
| Shadowgate (2014) | 2014 |
| Shadowgate 64: Trials of the Four Towers | 1999 |
| Shadowgate Classic | 1999 |
| Shadows on the Vatican: Act 1 - Greed | 2012 |
| Shadows on the Vatican: Act II - Wrath | 2014 |
| Shady Brook | 2005 |
| A Shakespeare Murder Mystery: The Seven Noble Kinsmen | 2005 |
| Shanghai: Dynasty | 1997 |
| Shanghai: Great Moments | 1995 |
| Shanghai: Mah-Jongg Essentials | 1999 |
| Shanghai Second Dynasty | 1999 |
| Shannara | 1995 |
| The Shapeshifting Detective | 2018 |
| Shapik: The Moon Quest | 2020 |
| Shardlight | 2016 |
| She and the Light Bearer | 2019 |
| Sheep | 2000 |
| Sheep Quest | 2012 |
| Shenmue | 2000 |
| Sherlock Holmes: Consulting Detective | 1991 |
