| Game | Year |
|---|
| Rock 'n' Roll Will Never Die! | 2022 |
| The Rockin' Dead | 2011 |
| Rocknor's Bad Day | 2002 |
| The Rocky Interactive Horror Show | 1999 |
| The Rodinia Project | 2017 |
| Rogue Quest: The Vault of the Lost Tyrant | 2017 |
| Role Player: Full Immersion | 2021 |
| The Romantic Blue | 1994 |
| Rome: Caesar's Will | 2000 |
| The Room | 2003 |
| The Room (2012) | 2012 |
| The Room 2 | 2013 |
| ROOM 208 | 2019 |
| A Room Beyond | 2017 |
| Rooms: The Main Building | 2008 |
| Rooms: The Unsolvable Puzzle | 2015 |
| RoonSehv: Neterra | 2015 |
| Root Letter | 2016 |
| The Roottrees are Dead | 2025 |
| Rosaura Docelestial: Rescue From Despair | 2017 |
| Rose and Lotus: Petals of Memories | 2023 |
| Rosewater | 2025 |
| Royal Trouble 2: Honeymoon Havoc | 2015 |
| Rugrats Adventure Game | 1997 |
| Ruka | 2021 |
| Rumpelstiltskin's Labyrinth of the Lost | 1995 |
| Rumu | 2017 |
| Runaway 1: A Road Adventure | 2001 |
| Runaway 2: The Dream of the Turtle | 2006 |
| Runaway 3: A Twist of Fate | 2009 |
| Rusts of Corruption | 2024 |
| Rusty Lake: Roots | 2016 |
| Rusty Lake Hotel | 2015 |
| Rusty Lake Paradise | 2018 |
| Sable | 2021 |
| Sabrina The Teenage Witch: Spellbound | 1998 |
| The Sacred Mirror of Kofun | 1996 |
| Sacrificial Lighthouse | 2021 |
| The Saddle Club: Willowbrook Stables | 2002 |
| Saddle Up: Time to Ride | 2004 |
| Sadhana: The Way Back (2020) | 2020 |
| The Safe Place | 2023 |
| Safecracker | 1997 |
| Safecracker: The Ultimate Puzzle Adventure | 2006 |
| Sagebrush | 2018 |
| Saihate Station | 2025 |
| The Sailor's Dream | 2014 |
| Salammbô: Battle for Carthage | 2002 |
| Sally Face | 2016 |
| Sam and Max, Season 1 Episode 1: Culture Shock | 2006 |
| Sam and Max, Season 1 Episode 2: Situation: Comedy | 2006 |
| Sam and Max, Season 1 Episode 3: The Mole, the Mob, and the Meatball | 2007 |
| Sam and Max, Season 1 Episode 4: Abe Lincoln Must Die | 2007 |
| Sam and Max, Season 1 Episode 5: Reality 2.0 | 2007 |
| Sam and Max, Season 1 Episode 6: Bright Side of the Moon | 2007 |
| Sam and Max, Season 2 Episode 1: Ice Station Santa | 2007 |
| Sam and Max, Season 2 Episode 2: Moai Better Blues | 2008 |
| Sam and Max, Season 2 Episode 3: Night of the Raving Dead | 2008 |
| Sam and Max, Season 2 Episode 4: Chariots of the Dogs | 2008 |
| Sam and Max, Season 2 Episode 5: What's New, Beelzebub? | 2008 |
| Sam and Max, Season 3 Episode 1: The Penal Zone | 2010 |
| Sam and Max, Season 3 Episode 2: The Tomb of Sammun-Mak | 2010 |
| Sam and Max, Season 3 Episode 3: They Stole Max's Brain! | 2010 |
| Sam and Max, Season 3 Episode 4: Beyond the Alley of the Dolls | 2010 |
| Sam and Max, Season 3 Episode 5: The City That Dares Not Sleep | 2010 |
| Sam and Max Hit the Road | 1993 |
| Sam and Max Season 2: Beyond Time and Space | 2021 |
| The Samaritan Paradox | 2014 |
| Sammy Jukes: Twin Lakes | 2024 |
| Samorost 1 | 2003 |
| Samorost 2 | 2005 |
| Samorost 3 | 2016 |
| Samsara Room (2020) | 2020 |
| SAMUDRA | 2021 |
| Samurai Jack | 2020 |
| The Sancho's Island | 2005 |
| Sandra and Woo in the Cursed Adventure | 2017 |
| Sanitarium | 1998 |
| Sanity: Aiken's Artifact | 2000 |
| Sanity of Morris | 2021 |
| Santa Fe Mysteries: Sacred Ground | 1996 |
| Santa Fe Mysteries: The Elk Moon Murder | 1996 |
| Santa's Secret Valley | 1995 |
| Santo Island Incident | 2022 |
| Sanya | 2024 |
| Saucer-Like | 2017 |
| Sayonara Okaasan | 2024 |
| Scéal | 2016 |
| SCARF | 2021 |
| Scarlet Hood and the Wicked Wood | 2021 |
| Scarlett Adventures: Episode 1 - Scarlett and the Spark of Life | 2010 |
| Scarred | 2025 |
| Scary Shadow Spot: Bitter Glass | 2025 |
| Scary Shadow Spot: Last Farewell | 2024 |
| Scavenger Hunter | 2006 |
| Scene Investigators | 2023 |
| A Sceptic's Guide to Magic | 2019 |
| Schizm 1: Mysterious Journey | 2001 |
| Schizm 2: Chameleon | 2003 |
| Schrödinger's Cat and The Raiders Of The Lost Quark | 2014 |
